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Reversible MRI findings of porphyric encephalopathy. A report of two cases
1Bakirkoy Research and Training Hospital for Psychiatry, Neurology and Neurosurgery; Istanbul, Turkey - ayssoysal@gmail.com.
Abstract:
We describe the magnetic resonance imaging (MRI) findings in two patients admitted to our institution with neuropsychiatric symptoms and severe abdominal pain diagnosed as acute intermittent porphyria (AIP). MRI revealed multiple lesions which regressed following treatment. We suggest reversible cerebral vasospasm underlies the MRI abnormalities and the cerebral symptoms in porphyria.
Insights
Magnetic resonance imaging (MRI) revealed reversible brain lesions in patients with acute intermittent porphyria (AIP). These findings correlated with neuropsychiatric symptoms and abdominal pain, suggesting vasospasm as a cause.
Area of Science:
- Neurology
- Radiology
- Metabolic Disorders
Background:
- Acute intermittent porphyria (AIP) is a rare genetic disorder.
- AIP can manifest with severe neurological and psychiatric symptoms.
- Abdominal pain is a common presenting symptom of AIP.
Purpose of the Study:
- To describe the magnetic resonance imaging (MRI) findings in patients with acute intermittent porphyria (AIP).
- To investigate the potential cause of cerebral symptoms and MRI abnormalities in AIP.
Main Methods:
- Case report of two patients with AIP.
- Magnetic resonance imaging (MRI) was used to evaluate brain abnormalities.
- Clinical symptoms and MRI findings were monitored during treatment.
Main Results:
- MRI revealed multiple, transient brain lesions in both patients.
- Lesions regressed following treatment for AIP.
- Cerebral symptoms and abdominal pain improved with treatment.
Conclusions:
- Reversible cerebral vasospasm is a likely cause of MRI abnormalities in AIP.
- MRI findings can help diagnose and monitor AIP-related neurological complications.
- Early diagnosis and treatment of AIP are crucial for managing neurological symptoms.
