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Significance of radio-pathological correlations: differentiating severe central nervous system infection from acute

A M Tokumaru1, T Hasebe, H Terada

  • 1Department of Radiology, Tokyo Metropolitan Medical Center of Gerontology; Tokyo, Japan - tokumaru@tmgh.metro.tokyo.jp.

The Neuroradiology Journal
|November 22, 2013
PubMed

Insights

Diagnosing severe central nervous system (CNS) infections and septic emboli can be challenging, often mimicking acute infarctions on emergency MRI. This study correlates imaging findings with autopsy pathology for better differentiation.

Area of Science:

  • Neurology
  • Radiology
  • Pathology

Background:

  • Severe central nervous system (CNS) infections and septic emboli present diagnostic challenges.
  • Distinguishing these conditions from acute infarctions on emergency magnetic resonance (MR) imaging can be difficult.

Purpose of the Study:

  • To present two educational autopsy cases illustrating CNS infection and septic emboli.
  • To correlate pathological findings with MR imaging features.
  • To improve differentiation between CNS infections/emboli and acute infarctions.

Main Methods:

  • Case study of two patients with severe CNS infection and septic emboli.
  • Review of emergency MR imaging findings.
  • Autopsy examination to determine pathological diagnoses.
  • Radiopathological correlation of imaging and tissue findings.

Main Results:

  • Autopsy confirmed severe CNS infection and septic emboli in both cases.
  • MR imaging findings presented features that were initially difficult to distinguish from acute infarctions.
  • Detailed radiopathological correlation elucidated key differentiating features.

Conclusions:

  • Accurate differentiation of CNS infections and septic emboli from infarctions is crucial for appropriate patient management.
  • Understanding the pathological basis of MR findings aids in diagnosis.
  • Educational autopsy cases enhance diagnostic accuracy in neuroimaging.

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