Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The 2026 global roadmap for textile-integrated wearable technologies in health.

Physiological measurement·2026
Same author

Microglia up‑regulate thromboxane A2 synthesis genes in response to C6 glioma‑conditioned medium.

Acta neurobiologiae experimentalis·2026
Same author

Interdigitated capacitive strain sensor enables precise yoga-inspired motion tracking.

Npj biosensing·2026
Same author

Lighting effects on optimal facial regions for remote heart rate measurement.

NPJ cardiovascular health·2026
Same author

Defining functional states and roles of microglia in neuropsychiatric disorders.

Frontiers in cellular neuroscience·2026
Same author

Dataset effects outweigh algorithmic effects in determining fairness of healthcare machine learning.

NPJ digital medicine·2026

Related Experiment Video

Updated: May 5, 2026

A Pre-clinical Rat Model for the Study of Ischemia-reperfusion Injury in Reconstructive Microsurgery
08:05

A Pre-clinical Rat Model for the Study of Ischemia-reperfusion Injury in Reconstructive Microsurgery

Published on: November 8, 2019

9.7K

Low frequency mechanical actuation accelerates reperfusion in-vitro.

Marcin Marzencki, Behrad Kajbafzadeh, Farzad Khosrow-Khavar

  • 11Faculty of Appliced Science, Simon Fraser University, 8888 University Drive, Burnaby, BC, Canada. cmenon@sfu.ca.

Biomedical Engineering Online
|November 22, 2013
PubMed
Summary

Mechanical stimulation, specifically vessel deformation, significantly accelerates blood clot perfusion in acute myocardial infarction models. This pre-hospital therapy shows promise for improving outcomes by rapidly restoring vessel patency.

More Related Videos

Improved Rodent Model of Myocardial Ischemia and Reperfusion Injury
07:23

Improved Rodent Model of Myocardial Ischemia and Reperfusion Injury

Published on: March 7, 2022

8.8K
Real-Time Assessment of Spinal Cord Microperfusion in a Porcine Model of Ischemia/Reperfusion
10:27

Real-Time Assessment of Spinal Cord Microperfusion in a Porcine Model of Ischemia/Reperfusion

Published on: December 10, 2020

2.7K

Related Experiment Videos

Last Updated: May 5, 2026

A Pre-clinical Rat Model for the Study of Ischemia-reperfusion Injury in Reconstructive Microsurgery
08:05

A Pre-clinical Rat Model for the Study of Ischemia-reperfusion Injury in Reconstructive Microsurgery

Published on: November 8, 2019

9.7K
Improved Rodent Model of Myocardial Ischemia and Reperfusion Injury
07:23

Improved Rodent Model of Myocardial Ischemia and Reperfusion Injury

Published on: March 7, 2022

8.8K
Real-Time Assessment of Spinal Cord Microperfusion in a Porcine Model of Ischemia/Reperfusion
10:27

Real-Time Assessment of Spinal Cord Microperfusion in a Porcine Model of Ischemia/Reperfusion

Published on: December 10, 2020

2.7K

Area of Science:

  • Cardiovascular Research
  • Biomedical Engineering
  • Medical Devices

Background:

  • Acute myocardial infarction (AMI) necessitates rapid restoration of vessel patency to minimize myocardial damage and improve survival.
  • Current standard treatments include thrombolysis and percutaneous coronary intervention (PCI).
  • Field-initiated emergency therapies are needed for timely intervention.

Purpose of the Study:

  • To evaluate a novel method of accelerating reperfusion using low-frequency mechanical stimulus.
  • To assess the efficacy of direct vessel vibration versus vessel deformation in clot dissolution.

Main Methods:

  • An in-vitro stenosed, heparinized flow system simulating aortic pressure was used.
  • Mechanical stimulus was applied via direct vessel vibration or proximal/distal vessel deformation.
  • A reference system without mechanical stimulus was employed for comparison.

Main Results:

  • Direct mechanical vibration showed limited effectiveness in clot perfusion.
  • Vessel deformation induced a drastic increase in patency rate.
  • With vessel deformation at the occlusion site, 95% of clots perfused within 11 minutes.
  • Vessel deformation 60 cm from the occlusion site achieved 95% perfusion within 16 minutes.
  • The reference system showed only 2.3% clot perfusion within 20 minutes.

Conclusions:

  • Low-frequency mechanical actuation, particularly vessel deformation, shows potential as an adjunct therapy for AMI.
  • This method could be a simple and efficient pre-hospitalization intervention.
  • Further in-vitro results suggest promising applications in emergency cardiovascular care.