Related Experiment Video

Updated: May 5, 2026

Identification of the Source of Secreted Proteins in the Kidney by Brefeldin A Injection
10:15

Identification of the Source of Secreted Proteins in the Kidney by Brefeldin A Injection

Published on: November 10, 2021

1.8K

Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) and kidney disease

Marta Ruiz-Ortega1, Alberto Ortiz, Adrian M Ramos

  • 1aIIS-Fundación Jiménez Díaz bREDinREN cUniversidad Autonoma de Madrid dIRSIN, Madrid, Spain.

Current Opinion in Nephrology and Hypertension
|November 22, 2013
PubMed
Abstract

Insights

Targeting the tumor necrosis factor-like weak inducer of apoptosis (TWEAK) shows promise for treating kidney injury. TWEAK targeting is well-tolerated in humans and may offer new therapies for various kidney diseases.

Area of Science:

  • Nephrology
  • Immunology
  • Molecular Biology

Background:

  • The cytokine tumor necrosis factor-like weak inducer of apoptosis (TWEAK) is implicated in kidney injury.
  • TWEAK has potential as a biomarker in kidney disease.
  • Previous studies linked TWEAK to kidney injury in animal models.

Purpose of the Study:

  • To review recent findings on TWEAK's role in kidney injury.
  • To explore the therapeutic potential of TWEAK targeting in kidney diseases.
  • To summarize the clinical progress of TWEAK inhibition.

Main Methods:

  • Review of experimental studies on TWEAK in kidney injury.
  • Analysis of recent research identifying TWEAK targets in renal cells.
  • Evaluation of clinical trial data for TWEAK inhibitors.

Main Results:

  • TWEAK promotes tubular cell injury and kidney inflammation.
  • TWEAK upregulates CXCL16 and downregulates Klotho in tubular cells.
  • TWEAK inhibition reduced kidney fibrosis in various injury models.
  • TWEAK may link chronic kidney disease and cancer.
  • TWEAK targeting is well-tolerated in a Phase I clinical trial.

Conclusions:

  • TWEAK targeting demonstrates clinical potential for immune and non-immune kidney injuries.
  • Further clinical trials are investigating TWEAK inhibition for lupus nephritis.
  • Novel therapeutic strategies targeting TWEAK are emerging for kidney disease.

More Related Videos

Modeling Hypoxia/Reoxygenation Injury in Proximal Tubular Epithelial Cells06:23

Modeling Hypoxia/Reoxygenation Injury in Proximal Tubular Epithelial Cells

Published on: November 21, 2025

723
Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway07:15

Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway

Published on: August 23, 2024

1.1K

Related Concept Videos

Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
2.4K
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
1.1K
Nephrons01:10

Nephrons

The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
8.4K
Acute Kidney Injury I: Introduction01:22

Acute Kidney Injury I: Introduction

Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
1.5K
Acute Kidney Injury III: Clinical Manifestations01:29

Acute Kidney Injury III: Clinical Manifestations

Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
1.8K
Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
1.4K