[Pre-diabetes mellitus influenced by hyperuricemia]

To investigate the relationship and the influence between pre-diabetes mellitus (PDM) and hyperuricemia (HUA).

157 PDM patients, aged 20 to 75 years old were selected from the Second Clinical Medical College of Harbin Medical University, from 2009 February to 2010 February and were divided into HUA group (76 cases) and NUA group (81 cases). All the patients had not been on thiazide drugs. T-test and Pearson correlation analysis were used to calculate the differences and correlation between uric acid and biochemical indicators.

In the HUA group,BMI was (27.74±2.88 ) kg/m(2), waist to height ratio (WSR) was(0.55 ± 0.41), TC was (6.61 ± 0.73) mmol/L, TG was(3.94 ± 1.97) mmol/L, LDL-C was (3.60 ± 0.45) mmol/L and homeostasis model assessment-insulin resistance index (HOMA-IR) was (3.09 ± 1.20). There were significant differences noticed in BMI, TG, TC, LDL-C, HOMA-IR at higher level in the HUA group than those in the NUA group. Pre-diabetes uric acid levels were positively correlated with TG, TC, LDL-C while HOMA-IR(TG:r = 0.29, TC:r = 0.33,LDL-C:r = 0.49, HOMA-IR:r = 0.51, P < 0.05) was negatively correlated (r = -0.30, P < 0.05)with the HbA1c.

The levels of PDM uric acid might both be related with TC, TG, LDL-C and HOMA-IR. The High level of uric acid status in vivo appeared closely related to HOMA-IR, which could further promote the progress of pre-diabetic patients to diabetes and causing dyslipidemia. Our findings suggested that the levels of pre-diabetes uric acid levels should be under concern.