[Surgery and adjuvant chemotherapy of disseminated testicular cancer]

The advent of combination chemotherapy regimens including Cis-Platinum (CDDP) in the 1970s brought about revolutionary improvement of short-term as well as long-term results of disseminated testicular cancer. PVB therapy (CDDP, Vinblastine and Bleomycin) introduced by L.H. Einhorn is reported to yield a 100% response rate but in Japan combination chemotherapy incorporating CDDP has not produced its maximal effects according to our results as well as analyses carried out by a multi-center cooperative study group. This is probably due to the toxicities and side effects of the drugs used. Facilities to deal with the high toxicities, i.e., severe myelosuppression, as well as enthusiasm on the part of the physician determined to arrive at a complete cure in each patient are prerequisite for the achievement of this final goal.