Assessing the susceptibility of transgenic mice overexpressing deer prion protein to bovine spongiform encephalopathy
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Updated: May 5, 2026
Assessing Transmissible Spongiform Encephalopathy Species Barriers with an In Vitro Prion Protein Conversion Assay
Published on: March 10, 2015
Christopher M Vickery1, Richard Lockey, Thomas M Holder
1Animal Health and Veterinary Laboratories Agency (AHVLA) Weybridge, Addlestone, Surrey, United Kingdom.
Abstract:
Several transgenic mouse models have been developed which facilitate the transmission of chronic wasting disease (CWD) of cervids and allow prion strain discrimination. The present study was designed to assess the susceptibility of the prototypic mouse line, Tg(CerPrP)1536(+/-), to bovine spongiform encephalopathy (BSE) prions, which have the ability to overcome species barriers. Tg(CerPrP)1536(+/-) mice challenged with red deer-adapted BSE resulted in 90% to 100% attack rates, and BSE from cattle failed to transmit, indicating agent adaptation in the deer.
