Related Experiment Video
Updated: May 5, 2026

Formation of Dispersible Taohong Siwu Tablets
Published on: February 3, 2023
A new brittleness index for compacted tablets
1Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen Ø, Denmark.
Abstract:
A dimensionless index that quantifies the brittle or ductile character of tablets is presented. The work of failure (WOF) of crushed or broken flat tablets is calculated by numerical integration of the force-displacement measurement in a flexure tester. The ratio between WOF and the crushing force (F) corrected for the diameter of the tablet (D) is proposed to express the brittle/ductile index (BDI). [Formula: see text] This dimensionless index quantitatively denotes the brittle/ductile character of the compacted material as the normalized deformation in percentage of a cylindrical tablet at the breaking point. For ideal brittle materials, the BDI value will be 0 and for complete plastic deformation, that is, a total compression of the tablet without fracture, BDI will be 100. The validity and discriminative power is demonstrated on mixtures of microcrystalline cellulose and lactose. The robust measure of brittleness with an acceptable accuracy is obtained with only a minor influence of the tablet diameter and the speed of platen.
Related Concept Videos
Compacting Factor test
The procedure begins by placing concrete into the upper hopper without any compaction. Once filled, the bottom door of this hopper is opened,...
Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence
Stress-Strain Diagram - Brittle Materials
Formulation and Manufacturing Process: Physical Attributes of Generic Tablets and Capsules
Strength of Cement
For compressive strength tests, ASTM C 109-05 standards prescribe a cement-sand mix ratio of 1:2.75 and a water/cement ratio of 0.485 for making 2-inch cubes. These cubes are mixed, cast, and cured in saturated lime water at 23°C until testing. Flexural strength testing, outlined in...
Factors Influencing Drug Absorption: Pharmaceutical Parameters

