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Mebeverine-loaded electrospun nanofibers: physicochemical characterization and dissolution studies
Upulitha Eranka Illangakoon1, Tahir Nazir, Gareth R Williams
1School of Human Sciences, Faculty of Life Sciences and Computing, London Metropolitan University, London, N7 8DB, United Kingdom; UCL School of Pharmacy, University College London, London, WC1N 1AX, United Kingdom.
Journal of Pharmaceutical Sciences
|November 22, 2013
Summary
Electrospun nanofibers of mebeverine hydrochloride (MB-HCl) were created using povidone (PVP) or Eudragit for fast-dissolving or sustained-release drug delivery systems (DDSs). PVP fibers dissolved rapidly, while Eudragit fibers offered pH-dependent, sustained release for intestinal applications.
Area of Science:
- Materials Science
- Pharmaceutical Sciences
- Nanotechnology
Background:
- Developing novel drug delivery systems (DDSs) is crucial for improving therapeutic efficacy and patient compliance.
- Electrospinning offers a versatile technique for fabricating nanofibers with controlled drug loading and release characteristics.
- Mebeverine hydrochloride (MB-HCl) is an antispasmodic drug often formulated for gastrointestinal relief.
Purpose of the Study:
- To prepare and characterize fast-dissolving and sustained-release DDSs of mebeverine hydrochloride (MB-HCl) using electrospun nanofibers.
- To evaluate the physical properties, drug-polymer compatibility, and in vitro dissolution behavior of the fabricated nanofiber systems.
- To explore the potential applications of these nanofiber DDSs for different routes of administration.
Main Methods:
- Electrospinning of MB-HCl incorporated into povidone (PVP) K60 or Eudragit(®) L 100-55 nanofibers.
- Characterization using scanning electron microscopy (SEM), differential scanning calorimetry (DSC), X-ray diffraction (XRD), infrared spectroscopy (IR), nuclear magnetic resonance (NMR), and high-performance liquid chromatography (HPLC).
- In vitro dissolution testing at different pH values to assess drug release profiles.
Main Results:
- Cylindrical nanofibers with smooth surfaces were obtained, with fiber diameter increasing with drug loading.
- Amorphous state of MB-HCl within the nanofibers was confirmed by DSC and XRD.
- Good drug-polymer compatibility and no degradation of MB-HCl during the electrospinning process were observed.
- PVP nanofibers exhibited rapid dissolution (<10 s), while Eudragit nanofibers showed pH-dependent release, with sustained release (~8 h) at pH 6.8.
Conclusions:
- Electrospun nanofibers of MB-HCl can be fabricated into both fast-dissolving (PVP) and sustained-release (Eudragit) DDSs.
- The Eudragit nanofibers demonstrate potential for oral DDSs targeting the intestinal tract due to their pH-dependent release.
- The PVP nanofibers are suitable for buccal delivery systems or suppositories owing to their rapid dissolution characteristics.
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