In situ mixed donor synthesis of ampicillin with ethylene glycol co-solvent
Andria L Deaguero1, Andreas S Bommarius
1Parker H. Petit Institute of Bioengineering and Biosciences, School of Chemical and Biomolecular Engineering, Atlanta, Georgia.
Biotechnology and Bioengineering
|November 22, 2013
Abstract:
Ethylene glycol has the ability to act as a reactant when employed as a co-solvent for the enzymatic synthesis of ampicillin from (R)-phenylglycine methyl ester and 6-aminopenicillanic acid. The side reaction positively affects yield because its product, (R)-phenylglycine hydroxyethyl ester, is an intermediate for ampicillin synthesis.


