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Exercise deactivates leukocytes in asthma
R P Vieira1, R A Silva2, M C Oliveira-Junior1
1Nove de Julho University, São Paulo, Brazil.
International Journal of Sports Medicine
|November 22, 2013
Summary
Aerobic training (AT) significantly reduces airway inflammation and Th2 immune responses in a mouse model of allergic asthma. This is achieved by decreasing leukocyte activation and the expression of key inflammatory mediators.
Area of Science:
- Immunology
- Respiratory Medicine
- Exercise Physiology
Background:
- Leukocytes are crucial in asthma development.
- Aerobic training (AT) is known to reduce leukocyte recruitment in airways.
- The specific effects of AT on leukocyte activation in asthma remain largely unknown.
Purpose of the Study:
- To investigate the impact of 4 weeks of AT on airway inflammation.
- To assess changes in pulmonary and systemic Th2 cytokines.
- To examine the effects of AT on leukocyte expression of inflammatory mediators in an experimental asthma model.
Main Methods:
- Utilized a mouse model of allergic asthma.
- Administered a 4-week aerobic training (AT) program.
- Analyzed bronchoalveolar lavage fluid (BALF) and serum for cytokine levels.
- Assessed leukocyte expression of various inflammatory mediators via flow cytometry and molecular techniques.
Main Results:
- AT reduced levels of IL-4, IL-5, and IL-13 in BALF and serum IL-5.
- AT increased bronchoalveolar lavage fluid (BALF) and serum IL-10 levels.
- AT decreased leukocyte expression of Th2 cytokines, chemokines, adhesion molecules, reactive oxygen/nitrogen species, iNOS, NF-kB, and growth factors.
Conclusions:
- Aerobic training effectively reduces peribronchial leukocyte activation in allergic asthma.
- AT leads to decreased airway inflammation and a dampened Th2 immune response.
- These findings suggest AT as a potential therapeutic strategy for managing asthma.
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