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Indole alkaloids from cell suspension cultures of Rauwolfia serpentina benth
J Stöckigt1, A Pfitzner, J Firl
1Lehrstuhl Pharmazeutische Biologie, Ludwig-Maximilians-Universität, D-8000, München, Federal Republic of Germany.
Abstract:
Twelve indole alkaloids belonging to the Ajmaline-, Sarpagine-, Yohimbine-, and Heteroyohimbine-type have been isolated and identified from cell suspension cultures of Rauwolfia serpentina. Ten of the alkaloids were found for the first time in cultured R. serpentina cells. The yield of the main alkaloid vomilenine was 51 times more than that of differentiated plants. Crude enzymes isolated from this cell suspension culture completely metabolize the biogenetic precursor strictosidine under formation of several alkaloidal compounds.
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