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Biosynthesis of rutacridone in tissue cultures of Ruta graveolens L
A Baumert1, I N Kuzovkina, G Krauss
1Institut für Biochemie der Pflanzen, Akademie der Wissenschaften der DDR, DDR-4010 Halle (Saale), Weinberg 3, GDR.
Abstract:
The dihydrofuroacridone, rutacridone, is the main alkaloid in tissue cultures of Ruta graveolens L. strain R-19. The biosynthesis of this particular acridone alkaloid was investigated by using calluses and suspension cultures of strain R-19. Anthranilic acid is specifically incorporated into ring A of rutacridone. Some further evidence was provided that acetate via a polyketide is involved in acridone biosynthesis. Mevalonic acid gave a poor incorporation into rutacridone. Thus the origin of the isopropyldihydrofuran moiety of the investigated alkaloid is still obscure.
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