Malignant Brenner tumor. A histologic, morphometrical, immunohistochemical, and ultrastructural study

Area of Science:

• Gynecologic Oncology
• Endocrinology
• Pathology

Background:

• Malignant Brenner tumors are rare ovarian neoplasms.
• Postmenopausal vaginal bleeding can indicate gynecologic pathology.
• Hyperestrogenism is associated with endometrial abnormalities.

Observation:

• A postmenopausal woman presented with vaginal bleeding and atypical endometrial hyperplasia.
• Histologic, morphometric, and immunohistochemical analyses were performed on the malignant Brenner tumor.
• Preoperative hormonal profile showed high urinary estrogen and low gonadotropins (LH, FSH).

Findings:

• The malignant Brenner tumor demonstrated aromatase activity, confirming endogenous estrogen synthesis.
• Urinary estrogen decreased and serum LH/FSH increased post-tumor resection.
• Estrogen receptors were not detected in the tumor tissue.
• Morphometry is proposed as a tool for grading the urothelial-like epithelium.

Implications:

• This finding suggests a potential mechanism for hormone-related symptoms in patients with malignant Brenner tumors.
• Understanding the tumor's endocrine function is crucial for diagnosis and management.
• Morphometric analysis may improve the classification and prognostic assessment of these tumors.