Related Experiment Video
Updated: May 5, 2026

Color Spot Test As a Presumptive Tool for the Rapid Detection of Synthetic Cathinones
Published on: February 5, 2018
Study of collision-induced dissociation of electrospray-generated protonated cathinones
1Chemistry Department, The John Paul II Catholic University of Lublin, al. Krasnicka 102, 20-718, Lublin, Poland; Laboratory of Separation and Spectroscopic Method Applications, Center for Interdisciplinary Research, The John Paul II Catholic University of Lublin, al. Krasnicka 102, 20-718, Lublin, Poland.
Abstract:
The collision-induced dissociation (CID) pathways of electrospray-generated protonated cathinones were examined to help elucidate the structures of new cathinone-based designer drugs by high performance liquid chromatography coupled with high-resolution tandem mass spectrometry. Quadrupole time-of-flight product spectra were obtained for 39 substituted cathinones and were analyzed to derive general CID fragmentation pathways. Nine classes of cathinones were characterized based on structural criteria, including the molecular double bond equivalent and the characteristics of the amine group. For each class of cathinones, we determined the characteristic CID fragmentation pathways, and identified the primary and some specific higher-order product ions.
Related Concept Videos
Tandem Mass Spectrometry
Electrospray Ionization (ESI) Mass Spectrometry
ESI utilizes electrical energy to transfer ions from the liquid phase of the sample into the...
Chemical Ionization (CI) Mass Spectrometry
Ion-Exchange Chromatography
Mass Spectrometry: Carboxylic Acid, Ester, and Amide Fragmentation
For example,...
Capillary Electrophoresis: Applications
Capillary zone electrophoresis (CZE) separates ionic components based on their electrophoretic mobility. It has been used to separate proteins, amino acids,...

