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Unilateral hydronephrosis caused by invasive mole: a case report
Hai-Yan Zhang1, Wei Wu, Jin Zhu
1Department of Gynecology, The Obstetrics and Gynecology Hospital, Shanghai Medical College, Fudan University No.419 Fangxie Road, Shanghai, China.
International Journal of Clinical and Experimental Medicine
|November 22, 2013
Summary
Gestational trophoblastic neoplasm, like invasive mole, is curable, but some cases resist chemotherapy. This report details a successful combination treatment for a patient with hydronephrosis after a hydatidiform mole.
Area of Science:
- Gynecology
- Oncology
- Reproductive Medicine
Background:
- Gestational trophoblastic neoplasm (GTN) encompasses highly curable pregnancy-related tumors.
- Approximately 20% of GTN cases exhibit resistance or relapse following initial chemotherapy.
- Salvage chemotherapy, potentially combined with surgery, is necessary for resistant/relapsed GTN.
Observation:
- A patient presented with unilateral hydronephrosis one week post-curettage for a hydatidiform mole.
- This clinical presentation suggested a potential complication or progression of the gestational trophoblastic disease.
Findings:
- The patient received a combination treatment regimen involving chemotherapy and surgical intervention.
- This integrated therapeutic approach led to a complete cure of the invasive mole and resolution of hydronephrosis.
Implications:
- The case highlights the effectiveness of combined chemotherapy and surgery in managing challenging GTN cases.
- Further research is warranted to determine optimal salvage regimens for chemotherapy-resistant or relapsed GTN.
- This approach offers a potential treatment pathway for patients with GTN complications like hydronephrosis.
