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Gastric Mucosa Quantitative Polymerase Chain Reaction Analysis for Detecting Helicobacter pylori and Antibiotic Resistance
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Gastric Mucosa Quantitative Polymerase Chain Reaction Analysis for Detecting Helicobacter pylori and Antibiotic Resistance

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Helicobacter pylori and Egyptian infantile colic

Adel S A Ali1, Maher B M Borei

  • 1Department of Pediatrics, Faculty of Medicine, Zagazig University, Zagazig, Egypt. Adel_sherif@yahoo.com

Journal of the Egyptian Society of Parasitology
|November 23, 2013
PubMed

Insights

Helicobacter pylori (H. pylori) infection may play a role in infantile colic. This study found H. pylori stool antigen in 62% of colicky infants compared to 20% of healthy controls.

Area of Science:

  • Pediatrics
  • Gastroenterology
  • Microbiology

Background:

  • Infantile colic is a common issue causing parental distress, with unclear causes despite extensive research.
  • Excessive infant crying can lead to severe stress and, in some cases, infant abuse.
  • The pathogenesis of infantile colic remains poorly understood after decades of investigation.

Purpose of the Study:

  • To investigate the potential role of Helicobacter pylori (H. pylori) infection in the development of infantile colic.
  • To explore H. pylori as a contributing factor to the unexplained etiology of infantile colic.

Main Methods:

  • A case-control study involving 50 infants diagnosed with infantile colic and 50 healthy controls.
  • H. pylori stool antigen testing was performed on all participating infants.
  • Clinical examinations and history taking were conducted for all infants.

Main Results:

  • H. pylori stool antigen was detected in 62% of infants with colic versus 20% in the control group (P<0.0001).
  • The study identified potential risk factors for H. pylori infection in infants, including normal vaginal delivery, male sex, vomiting, and breastfeeding.

Conclusions:

  • This research provides evidence supporting H. pylori's involvement in the pathogenesis of infantile colic.
  • Further investigation into H. pylori screening and treatment for colicky infants may be warranted.

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