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Chromophobe renal cell carcinoma: multiphase MDCT enhancement patterns and morphologic features
Siva P Raman1, Pamela T Johnson, Mohamad E Allaf
11 Department of Radiology, Johns Hopkins University, JHOC 3251, 601 N Caroline St, Baltimore, MD 21287.
AJR. American Journal of Roentgenology
|November 23, 2013
Summary
This study describes the CT imaging features of chromophobe renal cell carcinoma (RCC). These tumors show varied characteristics but tend to be homogeneous with central scars, falling between clear cell and papillary RCC in enhancement patterns.
Area of Science:
- Radiology
- Oncology
- Medical Imaging
Background:
- Chromophobe renal cell carcinoma (RCC) is a distinct subtype of kidney cancer.
- Understanding its imaging features is crucial for diagnosis and management.
Purpose of the Study:
- To retrospectively analyze the morphologic features, enhancement patterns, and clinical outcomes of pathologically confirmed chromophobe RCC.
- To provide a comprehensive description of CT findings for this rare RCC subtype.
Main Methods:
- Retrospective review of 35 patients with pathologically proven chromophobe RCC.
- Analysis of preoperative renal protocol CT scans (unenhanced, arterial, venous, delayed phases).
- Evaluation of tumor characteristics, attenuation values, and patient survival data.
Main Results:
- Mean patient age was 60.2 years; 60% were male.
- 46% of tumors were incidentally detected; none had distant metastases at diagnosis or follow-up (mean 2.0 years).
- Tumors frequently showed homogeneity (46%), were mostly solid (85%), and often had central scars or necrosis (34%).
Conclusions:
- Chromophobe RCC exhibits greater CT feature variability than previously recognized.
- These tumors demonstrate a propensity for homogeneity and central scars.
- Enhancement characteristics overlap with clear cell and papillary RCC but are distinct.
