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Coexistence of familial Mediterranean fever and rheumatoid arthritis

Kiyoshi Migita1, Seigo Abiru, Osamu Sasaki

  • 1Department of Rheumatology, Clinical Research Center, NHO National Nagasaki Medical Center , Kubara 2-1001-1, Omura 856-8652 , Japan.

Modern Rheumatology
|November 23, 2013
PubMed

Insights

Familial Mediterranean fever (FMF), a rare autoinflammatory disorder, co-occurred with rheumatoid arthritis (RA) in a Japanese patient. Colchicine treatment proved effective for managing FMF symptoms in this unique case.

Area of Science:

  • Rheumatology
  • Genetics
  • Immunology

Background:

  • Familial Mediterranean fever (FMF) is an autoinflammatory disease causing recurrent fever, polyserositis, and arthritis.
  • While seronegative spondyloarthropathy is known to occur with FMF, its coexistence with rheumatoid arthritis (RA) is exceptionally rare.

Observation:

  • This case report details a Japanese female diagnosed with rheumatoid arthritis who experienced periodic fevers.
  • The patient presented with symptoms suggestive of FMF alongside her established RA diagnosis.

Findings:

  • Genetic analysis identified compound heterozygous mutations in the MEFV gene (E148Q/G304R/P369S/R408Q) in the patient.
  • These mutations are associated with Familial Mediterranean fever.

Implications:

  • This case highlights the rare co-occurrence of FMF and RA, expanding the clinical spectrum of both conditions.
  • Successful colchicine treatment in this patient suggests its potential efficacy for managing FMF in the context of RA.
  • Further research into the genetic and clinical interplay between FMF and RA may be warranted.

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