[Serum proteomic analysis of cicatricial airway stenosis]
Li-huan Wang1, Jie Zhang, Juan Wang
1Department of Respiratory Medicine, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China.
Objective:
To establish serum protein fingerprint profile in patients with cicatricial airway stenosis and compared with healthy control.
Methods:
Serum samples of 17 cicatricial airway stenosis patients and 17 healthy persons were analyzed by SELDI-TOF-MS to select the differently expressed proteins through Biomarker Wizard software.
Results:
Compared with healthy control, 49 protein biomarkers were identified. Among them, 25 proteins were up-regulated, 24 proteins were down-regulated. These proteins were confirmed by searching database.
Conclusions:
There are obvious differentially expressed proteins in patients with cicatricial airway stenosis and controls, which may related with the development of airway scar.
