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Updated: May 5, 2026

Induction and Assessment of Levodopa-induced Dyskinesias in a Rat Model of Parkinson's Disease
Published on: October 14, 2021
Behavioral disorders in Parkinson's disease: the role of dopamine
Francesca Antonelli1, Antonio P Strafella
1Morton and Gloria Shulman Movement Disorder Unit, E.J. Safra Parkinson Disease Program, Toronto Western Hospital, UHN, University of Toronto, Ontario, Canada; Research Imaging Centre, Centre for Addiction and Mental Health, University of Toronto, Ontario, Canada; Parkinson's Disease and Movement Disorders Unit, Neurology Clinic, Hospital Clinic Universitari, University of Barcelona, Barcelona, Spain.
Abstract:
Dopaminergic neurons play a major role in controlling movement and behavior. In Parkinson's disease (PD), dopaminergic denervation is responsible for a number of motor and non-motor symptoms including tremor, rigidity and akinesia and as well apathy, impulsivity and other behavioral complications frequently reported in these patients. In this review, we will summarize the possible proposed dopaminergic mechanisms responsible for these complications in PD, focusing mainly on the role of this neurotransmitter in behavioral symptoms.
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