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Blood-based biomarkers for Parkinson's disease
Lama M Chahine1, Matthew B Stern, Alice Chen-Plotkin
1Parkinson's Disease and Movement Disorders Center, Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
Parkinsonism & Related Disorders
|November 23, 2013
Summary
Finding reliable blood biomarkers for Parkinson
Area of Science:
- Neurology
- Biomarker Discovery
- Molecular Diagnostics
Background:
- Parkinson's disease (PD) diagnosis, severity assessment, and prognosis require reliable biomarkers.
- Blood is a minimally invasive specimen type, but challenges exist in identifying blood-based PD biomarkers.
- Existing candidate biomarkers from other diseases/fluids and novel discovery methods are being explored.
Purpose of the Study:
- To review techniques for blood-based biomarker discovery in Parkinson's disease.
- To discuss the challenges and successes encountered in this field.
- To highlight specific candidate blood-based biomarkers for PD.
Main Methods:
- Review of current literature on blood-based biomarker research in Parkinson's disease.
- Exploration of unbiased discovery techniques: metabolomics, proteomics, and gene expression profiling.
- Discussion of specific candidate biomarkers including alpha-synuclein, DJ-1, uric acid, and others.
Main Results:
- Several candidate molecules are being investigated as blood-based biomarkers for PD.
- Advanced techniques like proteomics and metabolomics offer avenues for unbiased biomarker discovery.
- Progress has been made, but challenges in validating blood biomarkers for PD persist.
Conclusions:
- Blood-based biomarkers hold significant promise for improving Parkinson's disease diagnosis and management.
- Continued research utilizing advanced omics technologies is crucial for identifying robust PD biomarkers.
- Overcoming current challenges is essential for the clinical translation of blood biomarkers in PD.
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