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Updated: May 5, 2026

Isolation and Functional Assessment of Human Breast Cancer Stem Cells from Cell and Tissue Samples
Published on: October 2, 2020
Studying the capability of different cancer hallmarks to initiate tumor growth using a cellular automaton simulation.
Ángel Monteagudo1, José Santos1
1University of A Coruña, Department of Computer Science, Campus de Elviña s/n, 15071 A Coruña, Spain.
Abstract:
We used a cellular automaton model for cancer growth simulation at cellular level, based on the presence of different cancer hallmarks acquired by the cells. The presence of the hallmarks in each of the cells determines cell mitotic and apoptotic behaviors. Depending on the presence of the different hallmarks and some associated parameters of the hallmarks, the system can evolve to different dynamics. We used the cellular automaton model to inspect the capability of different hallmarks to generate tumor growth in different conditions, using this study in a cancer stem cell context to analyze the capability of the hallmarks to tumor regrowth in different circumstances.
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