Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mechanism of Ciliary Motion01:05

Mechanism of Ciliary Motion

5.0K
The ciliary structures were first seen in 1647 by Antonie Leeuwenhoek while observing the protozoans. In lower organisms, these appendages are responsible for cell movement, while in higher organisms, these appendages help in the movement of the extracellular fluids within the body cavities.
The cilia are made up of microtubules in a 9+2 arrangement, with nine microtubule doublet ring bundles, surrounding a pair of central singlet microtubule bundles. The doublet microtubule bundles are...
5.0K
Mechanism of Ciliary Motion01:05

Mechanism of Ciliary Motion

2.6K
2.6K
Cell Motility through Blebbing01:16

Cell Motility through Blebbing

1.9K
Blebs are a type of membrane protrusion formed by the internal hydrostatic pressure of the cytoplasm. Blebs are observed in several cell types, including fibroblasts, immune cells, and single-celled organisms like the amoeba. The primary function of blebs is cell locomotion and apoptosis, but they are also found during necrosis and cell division. The life cycle of a bleb comprises an initiation phase followed by the expansion and retraction phases.
Blebbing Through the Matrix
In multicellular...
1.9K
Disassembly of Intermediate Filaments01:35

Disassembly of Intermediate Filaments

2.0K
Intermediate filaments (IFs) do not undergo spontaneous disassembly. Enzymes, kinases, and phosphatases add and remove phosphates from specific sites to regulate their disassembly. The IF concentration in the cytoplasm also regulates the disassembly. If the concentration crosses a threshold, it activates the protein kinases in the vicinity, allowing the phosphorylation of IFs.
Keratin proteins, found at the cell periphery near cell junctions, undergo a cycle of assembly and disassembly. In Type...
2.0K
Microtubules in Signaling01:22

Microtubules in Signaling

1.5K
The primary cilium, made up of microtubules, acts as antennae on the cell surfaces for relaying external stimuli into the cells. These fine hair-like structures are present, generally one per cell. These are non-motile cilia in a 9+0 microtubules arrangement, where the central pair of microtubules are absent. The primary cilia arise from the basal body embedded in the cell membrane. Intraflagellar transport (IFT) carries requisite proteins from the cytoplasm to the cilium because the primary...
1.5K
Actin Filament Depolymerization01:19

Actin Filament Depolymerization

3.0K
Actin filaments (F-actin) are composed of actin subunits. The dissociation of actin monomers can occur from either end of F-actin. The rate of dissociation is faster from the minus-end or the pointed end, where the actin subunits exist with a bound ADP, together known as ADP-actin. The depolymerization of F-actin is aided by proteins, including the actin-depolymerizing factor (ADF) and cofilin family of proteins, gelsolin, and glia maturation factor (GMF).
In F-actin, the ADF/cofilin proteins...
3.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A role for the <i>Stentor</i> syntaxin protein in post-wound cell survival.

Molecular biology of the cell·2026
Same author

Editorial for special issue "When should mathematical models be used in biology".

Seminars in cell & developmental biology·2026
Same author

Genome-wide analysis of mRNA regionalization in a giant single cell.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

A centrin-Sfi1 myoneme fishnet powers ultrafast calcium-triggered contraction in the giant ciliate <i>Spirostomum ambiguum</i>.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Size-dependent nucleus-vacuole interactions in budding yeast demonstrate a role for steric packing in organelle shape and positioning.

bioRxiv : the preprint server for biology·2026
Same author

Molecular pathways for learning in the single-cell Stentor coeruleus.

Current biology : CB·2026

Related Experiment Video

Updated: May 5, 2026

Observation of the Ciliary Movement of Choroid Plexus Epithelial Cells Ex Vivo
08:00

Observation of the Ciliary Movement of Choroid Plexus Epithelial Cells Ex Vivo

Published on: July 13, 2015

11.4K

Ciliary regulation: disassembly takes the spotlight.

Prachee Avasthi1, Wallace F Marshall1

  • 1Department of Biochemistry & Biophysics, University of California San Francisco, 600 16th Street, San Francisco, CA 94158, USA.

Current Biology : CB
|November 23, 2013
PubMed
Summary

A NIMA-related kinase regulates organelle size by controlling cilia length. This kinase activates cilium disassembly when the organelle exceeds its optimal size, maintaining cellular homeostasis.

More Related Videos

Microdissection of the Rodent Eye
11:03

Microdissection of the Rodent Eye

Published on: April 21, 2023

6.5K
Application of High-speed Super-resolution SPEED Microscopy in Live Primary Cilium
07:53

Application of High-speed Super-resolution SPEED Microscopy in Live Primary Cilium

Published on: January 16, 2018

7.5K

Related Experiment Videos

Last Updated: May 5, 2026

Observation of the Ciliary Movement of Choroid Plexus Epithelial Cells Ex Vivo
08:00

Observation of the Ciliary Movement of Choroid Plexus Epithelial Cells Ex Vivo

Published on: July 13, 2015

11.4K
Microdissection of the Rodent Eye
11:03

Microdissection of the Rodent Eye

Published on: April 21, 2023

6.5K
Application of High-speed Super-resolution SPEED Microscopy in Live Primary Cilium
07:53

Application of High-speed Super-resolution SPEED Microscopy in Live Primary Cilium

Published on: January 16, 2018

7.5K

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Genetics

Background:

  • Organelle size regulation is crucial for cellular function but remains poorly understood.
  • Cilia, involved in various cellular processes, require precise size control.

Purpose of the Study:

  • To elucidate the molecular mechanisms governing organelle size control, specifically in cilia.
  • To identify key regulators of ciliary length homeostasis.

Main Methods:

  • Genetic analysis was employed to identify factors influencing ciliary size.
  • Investigated the role of NIMA-related kinases in ciliary length regulation.

Main Results:

  • A specific NIMA-related kinase was identified as a critical regulator of ciliary size.
  • This kinase activates a disassembly pathway for cilia that become excessively long.

Conclusions:

  • NIMA-related kinases play a significant role in maintaining organelle size homeostasis.
  • The findings provide new insights into the molecular basis of ciliary length control.