Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Parkinson's Disease: Treatment01:24

Parkinson's Disease: Treatment

1.4K
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
1.4K
Alterations in Muscle Tone ll01:12

Alterations in Muscle Tone ll

31
Alterations in muscle tone are common manifestations of neurological disorders and reflect dysfunction within different nervous system regions. Spasticity, paratonia, and dystonia represent distinct forms of hypertonia, each with unique mechanisms, clinical features, and diagnostic importance.CharacteristicsSpasticity happens from upper motor neuron lesions and is characterized by velocity-dependent resistance to passive movement. Clinical features include:Exaggerated deep tendon reflexesClonus...
31
Neural Regulation01:37

Neural Regulation

34.8K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
34.8K
Neuromuscular Junction And Blockade01:29

Neuromuscular Junction And Blockade

5.9K
The site of chemical communication between a motor neuron and a muscle fiber is called the neuromuscular junction (NMJ). The end of the motor neuron at the NMJ divides into a cluster of synaptic end bulbs. The cytoplasm of these bulbs consists of synaptic vesicles enclosing acetylcholine molecules, the principal neurotransmitter released at the NMJ. The region opposite the synaptic bulb that ends in the muscle fiber is called the motor end plate, which has acetylcholine receptors. Within the...
5.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Minimizing Botulinum Toxin Wastage: Insights From a Movement Disorders Practice.

Movement disorders clinical practice·2025
Same author

Spinal cord stimulation plus conventional medical management versus conventional medical management alone for severe, non-surgical, refractory back pain: a randomized clinical trial followed by crossover.

Regional anesthesia and pain medicine·2025
Same author

ENLITE PD: A Randomized Clinical Trial of Light Therapy for Impaired Sleep in Parkinson's Disease.

Movement disorders : official journal of the Movement Disorder Society·2025
Same author

Assessment of real-world, prospective outcomes in patients treated with cervical radiofrequency ablation for chronic pain (RAPID).

Interventional pain medicine·2025
Same author

Assessment of real-world, prospective outcomes in patients treated with lumbar radiofrequency ablation for chronic pain (RAPID).

Interventional pain medicine·2025
Same author

Low-energy differential target multiplexed SCS derivative reduces pain and improves quality of life through 12 months in patients with chronic back and/or leg pain.

Pain practice : the official journal of World Institute of Pain·2024

Related Experiment Video

Updated: May 5, 2026

Non-Invasive Electrical Brain Stimulation Montages for Modulation of Human Motor Function
07:47

Non-Invasive Electrical Brain Stimulation Montages for Modulation of Human Motor Function

Published on: February 4, 2016

12.8K

Neuromodulation for movement disorders.

Rob Dallapiazza1, M Sean McKisic, Binit Shah

  • 1Department of Neurosurgery, University of Virginia School of Medicine, Charlottesville, VA, USA.

Neurosurgery Clinics of North America
|November 23, 2013
PubMed
Summary

Surgical neuromodulation, including deep brain stimulation, offers effective treatment for essential tremor and Parkinson disease. This approach uses reversible manipulation of central nervous system neurons for diagnosis and chronic symptom management.

Keywords:
DBSEssential tremorFocused ultrasoundNeuromodulationParkinson’s diseaseStereotactic surgery

More Related Videos

A Novel Approach to Assess Motor Outcome of Deep Brain Stimulation Effects in the Hemiparkinsonian Rat: Staircase and Cylinder Test
07:14

A Novel Approach to Assess Motor Outcome of Deep Brain Stimulation Effects in the Hemiparkinsonian Rat: Staircase and Cylinder Test

Published on: May 31, 2016

14.5K
The Muscle Cuff Regenerative Peripheral Nerve Interface for the Amplification of Intact Peripheral Nerve Signals
07:30

The Muscle Cuff Regenerative Peripheral Nerve Interface for the Amplification of Intact Peripheral Nerve Signals

Published on: January 13, 2022

2.2K

Related Experiment Videos

Last Updated: May 5, 2026

Non-Invasive Electrical Brain Stimulation Montages for Modulation of Human Motor Function
07:47

Non-Invasive Electrical Brain Stimulation Montages for Modulation of Human Motor Function

Published on: February 4, 2016

12.8K
A Novel Approach to Assess Motor Outcome of Deep Brain Stimulation Effects in the Hemiparkinsonian Rat: Staircase and Cylinder Test
07:14

A Novel Approach to Assess Motor Outcome of Deep Brain Stimulation Effects in the Hemiparkinsonian Rat: Staircase and Cylinder Test

Published on: May 31, 2016

14.5K
The Muscle Cuff Regenerative Peripheral Nerve Interface for the Amplification of Intact Peripheral Nerve Signals
07:30

The Muscle Cuff Regenerative Peripheral Nerve Interface for the Amplification of Intact Peripheral Nerve Signals

Published on: January 13, 2022

2.2K

Area of Science:

  • Neurosurgery
  • Neurology
  • Biomedical Engineering

Background:

  • Medically refractory essential tremor and Parkinson disease symptoms necessitate advanced treatment options.
  • Surgical neuromodulation provides a method for reversible manipulation of central nervous system (CNS) neurons.
  • Neuromodulation aids in intraoperative target localization and chronic treatment of movement disorders.

Purpose of the Study:

  • To review historical advancements in stereotactic surgery and neuromodulation techniques.
  • To emphasize electrical neuromodulation, specifically deep brain stimulation (DBS), as a primary surgical intervention.
  • To discuss the technique, surgical targets, clinical outcomes, and compare various neuromodulation modalities.

Main Methods:

  • Historical review of stereotactic surgery and neuromodulation modalities.
  • Focus on electrical neuromodulation (deep brain stimulation).
  • Discussion of surgical techniques, target identification, and patient outcomes.
  • Comparative analysis of different neuromodulation approaches.

Main Results:

  • Deep brain stimulation is highlighted as a major surgical intervention for movement disorders.
  • The article details the technique, common surgical targets, and observed clinical outcomes of DBS.
  • A comparison of various neuromodulation techniques is provided, evaluating their efficacy and applications.

Conclusions:

  • Surgical neuromodulation, particularly deep brain stimulation, is a key treatment for refractory essential tremor and Parkinson disease.
  • The evolution of stereotactic surgery has led to sophisticated neuromodulation techniques for movement disorder management.
  • Understanding different neuromodulation modalities is crucial for optimizing patient care and treatment strategies.