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Updated: May 5, 2026

Therapy Testing in a Spheroid-based 3D Cell Culture Model for Head and Neck Squamous Cell Carcinoma
Published on: April 20, 2018
Special groups: head and neck cancer
Loni C Arrese1, Cathy L Lazarus
1Department of Otolaryngology, JamesCare Head & Neck Clinic, JamesCare Voice and Swallowing Disorders Clinic, The Ohio State University Comprehensive Cancer Center, Arthur G. James Cancer Hospital, Richard J. Solove Research Institute, The Ohio State University, 300 West 10th Avenue, Columbus, OH 43210, USA.
Abstract:
Head and neck cancer is a unique cause of dysphagia. Altered swallow function can be secondary to the mechanical effects of a tumor invading normal anatomy needed for deglutition, or as a direct sequela of cancer treatment (surgery and/or radiation ± chemotherapy). This article outlines the incidence of head and neck cancer, effects of anatomic changes associated with common surgical intervention, and the consequences of treatment-induced dysphagia. Assessment and rehabilitation techniques applicable for this population are discussed.
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