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Updated: May 5, 2026

Adapting Human Videofluoroscopic Swallow Study Methods to Detect and Characterize Dysphagia in Murine Disease Models
Published on: March 1, 2015
Dysphagia in stroke, neurodegenerative disease, and advanced dementia
Kenneth W Altman1, Amanda Richards, Leanne Goldberg
1Department of Otolaryngology Head & Neck Surgery, Eugen Grabscheid MD Voice Center, The Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1189, New York, NY 10029, USA.
Abstract:
Aspiration risk from dysphagia increases with central and peripheral neurologic disease. Stroke, microvascular ischemic disease, a spectrum of neurodegenerative diseases, and advancing dementia all have unique aspects. However, there are distinct commonalities in this population. Increasing nutritional requirements to stave off oropharyngeal muscular atrophy and a sedentary lifestyle further tax the patient's abilities to safely swallow. This article reviews stroke, muscular dystrophy, myasthenia gravis, multiple sclerosis, amyotrophic lateral sclerosis, Parkinson's disease, and advanced dementia. Approaches to screening and evaluation, recognizing sentinel indicators of decline that increase aspiration risk, and options for managing global laryngeal dysfunction are also presented.
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