Related Experiment Video
Updated: May 5, 2026

Frequency and Distribution of Crossovers in Caenorhabditis elegans Meiosis by SNP Genotyping using Real-time PCR
Published on: July 11, 2025
Estimation of recombination frequency in genetic linkage studies
E V Nordheim1, D M O'Malley, R P Guries
1Department of Forestry, University of Wisconsin, 120 Russell Laboratories, 1630 Linden Drive, 53706, Madison, WI, USA.
Abstract:
A binomial-like model is developed that may be used in genetic linkage studies when data are generated by a testcross with parental phase unknown. Four methods of estimation for the recombination frequency are compared for data from a single group and also from several groups; these methods are maximum likelihood, two Bayesian procedures, and an ad hoc technique. The Bayes estimator using a noninformative prior usually has a lower mean squared error than the other estimators and because of this it is the recommended estimator. This estimator appears particularly useful for estimation of recombination frequencies indicative of weak linkage from samples of moderate size. Interval estimates corresponding to this estimator can be obtained numerically by discretizing the posterior distribution, thereby providing researchers with a range of plausible recombination values. Data from a linkage study on pitch pine are used as an example.
Related Concept Videos
Crossing Over
Conservative Site-specific Recombination and Phase Variation
The recognition sites for Cre recombinase called LoxP...
Hardy-Weinberg Principle
Gene Conversion
Determination of Expected Frequency
Carrier Generation and Recombination
This process is given by the generation rate G and is efficient due to the conservation of momentum between the valence band maximum and conduction band minimum.
Indirect generation involves an...

