Related Experiment Video

Updated: May 5, 2026

Setup of Capillary Electrophoresis-Inductively Coupled Plasma Mass Spectrometry CE-ICP-MS for Quantification of Iron Redox Species FeII, FeIII
04:48

Setup of Capillary Electrophoresis-Inductively Coupled Plasma Mass Spectrometry CE-ICP-MS for Quantification of Iron Redox Species FeII, FeIII

Published on: May 4, 2020

9.5K

Metabolic effects of high doses of manganese in rats

C L Keen1, D L Baly, B Lönnerdal

  • 1Department of Nutrition, University of California, 95616, Davis, California.

Biological Trace Element Research
|November 23, 2013
PubMed

Insights

Acute manganese toxicity significantly increases tissue manganese levels and blood glucose in rats, while decreasing insulin. This highlights manganese

Area of Science:

  • Toxicology
  • Biochemistry
  • Endocrinology

Background:

  • Manganese (Mn) is an essential trace element, but excessive exposure can lead to toxicity.
  • Understanding the metabolic impact of acute manganese toxicity is crucial for public health and occupational safety.

Purpose of the Study:

  • To investigate the effects of acute manganese toxicity on tissue manganese concentrations and plasma glucose levels in rats.
  • To examine the relationship between manganese levels, glucose metabolism, and insulin response.

Main Methods:

  • Adult male Sprague-Dawley rats were injected with manganese.
  • Tissue manganese concentrations and plasma glucose levels were measured.
  • Changes in molecular localization of manganese in the liver were analyzed.

Main Results:

  • A significant, albeit transitory, increase in manganese concentration was observed in all analyzed tissues post-injection.
  • Manganese injection led to rapid, dose-responsive increases in blood glucose.
  • Circulating insulin levels decreased following manganese injection.
  • Alterations in the molecular distribution of manganese in the liver, including increased protein-bound manganese and low molecular weight complexes, were noted.

Conclusions:

  • Acute manganese exposure significantly impacts carbohydrate metabolism.
  • Elevated tissue manganese levels are directly linked to hyperglycemia and altered insulin secretion.
  • These findings underscore the critical role of manganese in regulating glucose homeostasis.

More Related Videos

Measuring Liver Mitochondrial Oxygen Consumption and Proton Leak Kinetics to Estimate Mitochondrial Respiration in Holstein Dairy Cattle08:29

Measuring Liver Mitochondrial Oxygen Consumption and Proton Leak Kinetics to Estimate Mitochondrial Respiration in Holstein Dairy Cattle

Published on: November 30, 2018

10.6K
Functional Neuroimaging Using Ultrasonic Blood-brain Barrier Disruption and Manganese-enhanced MRI08:36

Functional Neuroimaging Using Ultrasonic Blood-brain Barrier Disruption and Manganese-enhanced MRI

Published on: July 12, 2012

14.4K

Related Concept Videos

Microbes and Other Elemental Cycles01:24

Microbes and Other Elemental Cycles

Microbial activity plays a pivotal role in the biogeochemical cycling of iron and manganese, especially at the redox gradients characteristic of stratified aquatic environments. These cycles are driven by microbial transformations between oxidized and reduced forms of the metals, allowing organisms to exploit them for metabolic energy and structural purposes.Iron Cycling Across Redox GradientsIn neutral, oxygen-rich surface waters, iron is predominantly found in its oxidized, insoluble ferric...
94
Radical Oxidation of Allylic and Benzylic Alcohols01:21

Radical Oxidation of Allylic and Benzylic Alcohols

Activated manganese(IV) oxide can selectively oxidize allylic and benzylic alcohols via a radical intermediate mechanism. Primary allylic alcohols are oxidized to aldehydes, while secondary allylic alcohols yield ketones. The redox reaction of potassium permanganate with an Mn(II) salt such as manganese sulfate (under either alkaline or acidic conditions), followed by thorough drying, yields the oxidizing agent: activated MnO2. While MnO2 is insoluble in the solvents used for the reaction, the...
2.3K
Drug Toxicity: Dose-Dependent Reactions01:24

Drug Toxicity: Dose-Dependent Reactions

Drug toxicities can be stratified into pharmacological, pathological, or genotoxic based on their mechanisms. The incidence and severity of these toxicities generally increase with the drug's concentration in the body and exposure time.Pharmacological toxicity is evident when the therapeutic effects of drugs overshoot into adverse reactions in a predictable, dose-dependent manner. Central nervous system (CNS) depression from barbiturates is a classic example, with effects escalating from...
245