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Low plasma Chromium in patients with coronary artery and heart diseases

M Simonoff1, Y Llabador, C Hamon

  • 1Chimie Nucléaire, ERA 144, CENBG, 33170, Bordeaux- Gradignan, France.

Biological Trace Element Research
|November 23, 2013
PubMed

Insights

Plasma chromium levels can help predict coronary artery disease (CAD). Lower chromium concentrations indicate a higher likelihood of CAD, potentially reducing the need for invasive cineangiographic examinations.

Area of Science:

  • Cardiovascular Medicine
  • Clinical Chemistry
  • Biomarker Discovery

Background:

  • Plasma chromium levels are being investigated as potential biomarkers.
  • Coronary artery disease (CAD) diagnosis often relies on invasive procedures.

Purpose of the Study:

  • To determine the relationship between plasma chromium concentrations and coronary artery disease.
  • To explore the potential of plasma chromium levels to non-invasively predict CAD risk.

Main Methods:

  • Plasma chromium concentrations were measured in 150 patients.
  • Patients were categorized into three groups: CAD, heart disease (HD) without CAD, and no CAD/HD (N) based on coronary artery cineangiography.
  • Weighted average chromium levels were calculated for each group.

Main Results:

  • Group N (no CAD/HD) had a significantly higher average plasma chromium level (8.51 ng/mL) compared to Group HD (1.72 ng/mL) and Group CAD (1.05 ng/mL).
  • A potential upper limit for plasma chromium was identified at 6 ng/mL, beyond which CAD is unlikely.

Conclusions:

  • Plasma chromium levels show a strong inverse correlation with the presence and severity of coronary artery disease.
  • Establishing an upper plasma chromium threshold could aid in risk stratification and potentially reduce the need for diagnostic cineangiography.

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