Related Experiment Video
Updated: May 5, 2026

Modeling Ascending Vaginal Infection, Preterm Birth, and Neonatal Morbidity in Mice
Published on: October 10, 2025
Preterm births - United States, 2006 and 2010
Insights
Preterm birth rates in the U.S. decreased from 2006 to 2010, but remain a significant cause of infant mortality and long-term health issues. Despite overall declines, early preterm births and racial disparities persist, requiring further investigation for interventions.
Area of Science:
- Public Health
- Neonatalogy
- Epidemiology
Background:
- Preterm birth (<37 weeks' gestation) is a leading cause of infant mortality in the U.S., contributing to approximately one-third of all infant deaths.
- Infants born preterm face increased risks of early mortality and lifelong neurological and cognitive challenges.
- The U.S. preterm birth rate saw a significant increase of approximately 30% between 1981 and 2006.
Purpose of the Study:
- To analyze trends in preterm birth rates in the U.S. from 2006 to 2010.
- To examine changes in both early preterm (<34 weeks) and late preterm (34-36 weeks) birth rates.
- To identify persistent disparities in preterm birth rates and inform potential intervention strategies.
Main Methods:
- Analysis of national birth data from 2006 and 2010.
- Calculation and comparison of preterm birth rates for overall, early preterm, and late preterm births.
- Examination of racial/ethnic differences in preterm birth rates.
Main Results:
- The U.S. preterm birth rate declined from 12.8% in 2006 to 12.0% in 2010, marking a reversal of the previous upward trend.
- The decrease was primarily driven by a reduction in late preterm births (9.15% to 8.49%), but early preterm birth rates also decreased (3.66% to 3.50%).
- Despite the decrease, the total number of preterm births in 2010 exceeded those in any year from 1981-2001, and significant racial/ethnic disparities persist.
Conclusions:
- While recent trends show a decrease in preterm birth rates, the overall number remains high, underscoring the ongoing public health challenge.
- Further research into persistent racial/ethnic disparities is crucial for developing targeted interventions.
- Continued monitoring and research are necessary to address the complex issue of preterm birth and its associated infant health outcomes.
Abstract:
Approximately one third of all infant deaths in the U.S. are related to preterm birth. Infants who survive a preterm birth are at greater risk than those born later in pregnancy for early death and lifelong effects such as neurologic and cognitive difficulties. The rate of preterm births (i.e., <37 completed weeks' gestation) increased approximately 30% during 1981-2006. In 2007, this trend began to reverse; the U.S. preterm birth rate decreased for the fourth consecutive year in 2010, decreasing from the 2006 high of 12.8% to 12.0% in 2010. A total of 4,265,555 births were reported for 2006, including 542,893 preterm births, and 3,999,386 births were reported for 2010, including 478,790 preterm births. Although most of the recent decrease in this rate was among infants born at 34 to 36 weeks' gestation (i.e., late preterm), with a decrease from 9.15% to 8.49% during 2006-2010, the rate of infants born at <34 weeks' gestation (i.e., early preterm) also decreased from 3.66% in 2006 to 3.50% in 2010. Despite improvements in the rate of preterm births, the total number of infants born preterm remains higher than any year during 1981-2001. Substantial differences in preterm birth rates by race/ethnicity persist; additional examination of these differences can provide insight into potential areas for interventions.
Related Concept Videos
Teratogenicity
Development of the Oral Microbiota
Development of Human Microbiota
Prevalence and Incidence
Prevalence indicates the proportion of individuals in a population who have a specific disease or health...
Regression Toward the Mean

