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Epitope expression on primate lymphocyte surface antigens.

Y Murayama, K Fukao, A Noguchi

    Journal of Medical Primatology
    |January 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

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    This study examined primate immune cells using monoclonal antibodies, revealing distinct T-, natural killer/killer-, and B-cell marker expressions across species. Findings highlight significant variations in immune cell epitopes among different primate groups.

    Area of Science:

    • Immunology
    • Primatology
    • Cell Biology

    Background:

    • Peripheral blood mononuclear cells (PBMCs) are crucial for immune responses.
    • Monoclonal antibodies targeting cell surface markers are vital for immune cell identification.
    • Understanding primate immune systems aids comparative immunology and disease research.

    Purpose of the Study:

    • To investigate the cross-reactivity of human-specific Leu series monoclonal antibodies with PBMCs from 28 nonhuman primate species.
    • To characterize the expression patterns of T-cell, natural killer/killer-cell, and B-cell epitopes across diverse primate groups.

    Main Methods:

    • Peripheral blood mononuclear cells from 28 nonhuman primates were isolated.
    • Ten types of Leu series monoclonal antibodies, specific to human T-, natural killer/killer-, and B-cells, were used for cross-reactivity analysis.

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  • Flow cytometry or similar techniques were employed to detect epitope expression.

    • Main Results:

    • Chimpanzees expressed all ten examined epitopes.
    • Orangutans lacked Leu4 and Leu7; gibbons lacked Leu4, Leu7, and Leu12.
    • Old World monkeys lacked Leu1 and Leu10; New World monkeys lacked Leu2a.
    • Macaque species showed varied Leu3a/Leu2a ratios, enabling classification into three groups.
    • Owl monkeys uniquely expressed Leu3a; prosimians expressed only HLA-DR.

    Conclusions:

    • Significant interspecies variation exists in immune cell surface marker expression among nonhuman primates.
    • Primate immune cell phenotyping using human-specific antibodies reveals evolutionary differences.
    • These findings provide a basis for comparative immunology studies and the use of nonhuman primates as models for human diseases.