Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Spermatogenesis01:41

Spermatogenesis

91.1K
Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male...
91.1K
Spermatogenesis01:22

Spermatogenesis

8.4K
Spermatogenesis is a complex process that involves the development of sperm cells from undifferentiated stem cells in the seminiferous tubules of the testes. The process is essential for the production of mature and functional sperm cells that are capable of fertilizing an egg.
The process of spermatogenesis can be divided into mitosis, meiosis, and spermiogenesis. During mitosis, the spermatogonia or stem cells divide to produce two identical daughter cells, type A and B spermatogonia. Type-A...
8.4K
Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

2.9K
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
2.9K
Hypoxia01:23

Hypoxia

2.4K
Hypoxia is a medical condition characterized by an inadequate oxygen supply to body tissues. It typically manifests as a bluish discoloration of the skin and mucosae, especially in fair-skinned individuals, when hemoglobin (Hb) saturation drops below 75%.
Types of Hypoxia
There are four primary types of hypoxia, each resulting from a different cause:
1. Anemic hypoxia: This type occurs due to insufficient oxygen delivery caused by a lack of red blood cells (RBCs) or RBCs with abnormal or...
2.4K
Oogenesis02:07

Oogenesis

58.5K
In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
58.5K
Testosterone: Functions and Regulation01:26

Testosterone: Functions and Regulation

3.5K
The intricate hormonal interplay essential for male reproductive health begins with the release of gonadotropin-releasing hormone (GnRH) by the hypothalamus. This hormone prompts the pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). LH targets the Leydig cells in the testes, stimulating them to produce and release testosterone. In concert with testosterone, FSH acts on the Sertoli cells within the seminiferous tubules to facilitate the release of...
3.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Chokeberry Products and By-Products as the Potential Pharmaceuticals for Kidney Protection-An Experimental Study in Rats.

Plants (Basel, Switzerland)·2024
Same author

The Association of Death Receptors and TGF-β1 Expression in Urothelial Bladder Cancer and Their Prognostic Significance.

Biomedicines·2024
Same author

Expression of Basal Compartment and Superficial Markers in Upper Tract Urothelial Carcinoma Associated with Balkan Endemic Nephropathy, a Worldwide Disease.

Biomedicines·2024
Same author

The association between NOTCH3 expression and the clinical outcome in the urothelial bladder cancer patients.

Bosnian journal of basic medical sciences·2022
Same author

Expression of the CXCR4 and CXCR7 in renal cancers; can "the orphan receptor" predict the mortality?

Annals of diagnostic pathology·2021
Same author

Expression and prognostic value of CXCL12/CXCR4/CXCR7 axis in clear cell renal cell carcinoma.

Clinical and experimental nephrology·2021

Related Experiment Video

Updated: May 5, 2026

Evaluation of Intracellular Location of Reactive Oxygen Species in Solea Senegalensis Spermatozoa
10:24

Evaluation of Intracellular Location of Reactive Oxygen Species in Solea Senegalensis Spermatozoa

Published on: March 11, 2018

5.8K

Hypoxia and spermatogenesis.

Ljubinka Jankovic Velickovic1, Vladisav Stefanovic

  • 1Faculty of Medicine, Institute of Pathology, University of Nis, Nis, Serbia.

International Urology and Nephrology
|November 23, 2013
PubMed
Summary

Hypoxia and increased testicular temperature reduce sperm count and increase germ cell apoptosis. Understanding these factors, including Oct-4 expression, is key for male fertility and stem cell function.

Area of Science:

  • Reproductive Biology
  • Cell Biology
  • Andrology

Background:

  • Hypoxia, a state of low oxygen, is linked to vascular changes and elevated testicular temperature.
  • These conditions negatively impact sperm production and germ cell survival.
  • The testicular microenvironment's oxygen and temperature affect spermatogonial stem cell function.

Purpose of the Study:

  • To review the effects of physiological and pathological hypoxia on spermatogenesis.
  • To explore the relationship between hypoxia, testicular temperature, and male fertility.
  • To examine the role of hypoxia in spermatogonial stem cell maintenance and differentiation.

Main Methods:

  • Literature review of studies on hypoxia, testicular temperature, and spermatogenesis.

More Related Videos

Hypoxia Alters miRNAs Levels Involved in Non-Mendelian Inheritance of Autism Spectrum Disorder in Mice
09:13

Hypoxia Alters miRNAs Levels Involved in Non-Mendelian Inheritance of Autism Spectrum Disorder in Mice

Published on: July 11, 2025

26.9K
Induction of Hypoxia in Living Frog and Zebrafish Embryos
08:01

Induction of Hypoxia in Living Frog and Zebrafish Embryos

Published on: June 26, 2017

9.4K

Related Experiment Videos

Last Updated: May 5, 2026

Evaluation of Intracellular Location of Reactive Oxygen Species in Solea Senegalensis Spermatozoa
10:24

Evaluation of Intracellular Location of Reactive Oxygen Species in Solea Senegalensis Spermatozoa

Published on: March 11, 2018

5.8K
Hypoxia Alters miRNAs Levels Involved in Non-Mendelian Inheritance of Autism Spectrum Disorder in Mice
09:13

Hypoxia Alters miRNAs Levels Involved in Non-Mendelian Inheritance of Autism Spectrum Disorder in Mice

Published on: July 11, 2025

26.9K
Induction of Hypoxia in Living Frog and Zebrafish Embryos
08:01

Induction of Hypoxia in Living Frog and Zebrafish Embryos

Published on: June 26, 2017

9.4K
  • Analysis of the impact of altered microenvironmental conditions on germ cell apoptosis and stem cell function.
  • Investigation of molecular factors, such as Oct-4 expression, involved in stem cell regulation.

    • Main Results:

    • Hypoxia and increased testicular temperature lead to reduced sperm count and increased germ cell apoptosis.
    • Changes in oxygen and temperature influence spermatogonial stem cell function and differentiation.
    • Alterations in Oct-4 expression are an early indicator of hypoxia's effect on stem cell maintenance.

    Conclusions:

    • Hypoxia and associated testicular temperature changes significantly impair spermatogenesis and male fertility.
    • Targeting factors like Oct-4 may offer strategies for modulating stem cell function in hypoxic conditions.
    • Further research is needed to clarify the contralateral testis response to unilateral testicular injury.