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Updated: May 5, 2026

Identification of Kinase-substrate Pairs Using High Throughput Screening
Published on: August 29, 2015
PAS kinase: a nutrient sensing regulator of glucose homeostasis
Desiree DeMille1, Julianne H Grose
1Department of Microbiology and Molecular Biology, Brigham Young University, Provo, UT.
Abstract:
Per-Arnt-Sim (PAS) kinase (PASK, PASKIN, and PSK) is a member of the group of nutrient sensing protein kinases. These protein kinases sense the energy or nutrient status of the cell and regulate cellular metabolism appropriately. PAS kinase responds to glucose availability and regulates glucose homeostasis in yeast, mice, and man. Despite this pivotal role, the molecular mechanisms of PAS kinase regulation and function are largely unknown. This review focuses on what is known about PAS kinase, including its conservation from yeast to man, identified substrates, associated phenotypes and role in metabolic disease.
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