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Published on: August 27, 2019
Therapeutic target database update 2014: a resource for targeted therapeutics
Chu Qin1, Cheng Zhang, Feng Zhu
1Bioinformatics and Drug Design Group, Department of Pharmacy, and Center for Computational Science and Engineering, National University of Singapore, 117543 Singapore, Molecular Medicine Research Center, State Key Laboratory of Biotherapy, West China Hospital, West China School of Medicine, Sichuan University, Chengdu, China, NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, 117456, Singapore, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300071, People's Republic of China, State Key Laboratory of Medicinal Chemistry & Biology, Tianjin International Joint Academy of Biotechnology & Medicine, Tianjin 300457, People's Republic of China, Computation and Systems Biology, Singapore-MIT Alliance, National University of Singapore, Singapore and Innovative Drug Research Centre and College of Chemistry and Chemical Engineering, Chongqing University, Chongqing, People's Republic of China.
The updated Therapeutic Target Database enhances access to drug, target, and biomarker information. New search tools facilitate personalized medicine research by linking diseases to therapeutic targets and biomarkers.
Area of Science:
- Biomedical Informatics
- Pharmacology
- Drug Discovery
Background:
- Targeted therapeutics and personalized medicine are advancing rapidly.
- Effective development requires knowledge of efficacy targets and biomarkers.
- The Therapeutic Target Database (TTD) supports these efforts.
Purpose of the Study:
- To update the Therapeutic Target Database (TTD) for improved data access and utility.
- To enhance support for researchers and clinicians in the bench-to-clinic pipeline.
- To facilitate the development of stratified and personalized medicines.
Main Methods:
- Integrated International Classification of Disease (ICD-10-CM and ICD-9-CM) search functionalities.
- Expanded database content to include targets, biomarkers, drugs, drug scaffolds, and multitarget agents.
- Included data on drug activity against cell lines.
Main Results:
- The TTD now covers over 2300 targets, 20,600 drugs, and 20,000 multitarget agents.
- New search tools link nearly 900 targets, 1800 biomarkers, and 6000 drugs to 900 diseases.
- Detailed information on biomarkers, drug scaffolds, and drug activity is now available.
Conclusions:
- The updated TTD provides a comprehensive resource for targeted therapeutics research.
- Enhanced search capabilities facilitate the identification of relevant targets and biomarkers for personalized medicine.
- The database supports data access, processing, and exchange for the scientific community.
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