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Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache

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Headache as a risk factor for dementia: a prospective population-based study.

Knut Hagen¹, Eystein Stordal, Mattias Linde

¹Department of Neuroscience, Norwegian University of Science and Technology, Norway.

Cephalalgia : an International Journal of Headache

|November 23, 2013

Summary

Experiencing any headache may increase your risk of developing vascular dementia (VaD). This study found a significant association between headache and VaD, but not Alzheimer's disease (AD).

Keywords:

Alzheimer’s disease headache migraine vascular dementia

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Area of Science:

Neurology
Epidemiology
Public Health

Background:

Headache is not widely recognized as a dementia risk factor.
Previous research has not definitively linked headache to dementia development.

Purpose of the Study:

To investigate the association between headache and the subsequent risk of developing vascular dementia (VaD), Alzheimer's disease (AD), or other dementia types.
To determine if headache history predicts future dementia diagnosis.

Main Methods:

Prospective population-based cohort study using HUNT 2 data (1995-1997) and a Norwegian dementia register (1997-2010).
Participants (≥20 years) were categorized by headache status: headache-free, any headache, migraine, or non-migrainous headache.
Cox regression analysis was used to estimate hazard ratios (HRs) for dementia development.

Main Results:

Of 51,383 participants, 378 developed dementia.
Any headache was associated with an increased risk of vascular dementia (VaD) (aHR=2.3) and mixed dementia (VaD and AD) (aHR=2.0).
No significant association was found between any headache and the development of Alzheimer's disease (AD).

Conclusions:

Any headache is identified as a risk factor for the development of vascular dementia (VaD).
The findings suggest a potential link between headache and specific dementia subtypes, warranting further investigation.