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Increased serum HMGB1 is related to oxidative stress in patients with atrial fibrillation

Yongbo Wu1, Kai Zhang, Lin Zhao

  • 1Department of Cardiology, Huangshi Central Hospital, Affiliated Hospital of Hubei Polytechnic University, Huangshi, China.

The Journal of International Medical Research
|November 23, 2013
PubMed

Insights

Serum high mobility group box 1 protein (HMGB1) and oxidative stress markers are elevated in atrial fibrillation (AF) patients. HMGB1 levels correlate with oxidative stress, suggesting a potential therapeutic target for AF.

Area of Science:

  • Cardiology
  • Biochemistry
  • Molecular Biology

Background:

  • Atrial fibrillation (AF) is a common arrhythmia.
  • Oxidative stress plays a role in cardiovascular diseases.
  • High mobility group box 1 protein (HMGB1) is implicated in inflammation and cellular stress.

Purpose of the Study:

  • To examine the association between serum HMGB1 levels and markers of oxidative stress in patients with AF.
  • To determine if HMGB1 is a predictor of AF.

Main Methods:

  • Serum HMGB1, malondialdehyde (MDA), and superoxide dismutase (SOD) activity were measured in patients with paroxysmal or persistent AF and in control subjects.
  • Statistical analyses were performed to assess correlations and predictive values.

Main Results:

  • Patients with AF exhibited significantly higher serum HMGB1 concentrations and MDA activity compared to controls.
  • Serum SOD activity was significantly lower in AF patients.
  • HMGB1 concentration positively correlated with MDA activity and negatively with SOD activity in AF patients.
  • HMGB1, MDA, SOD, and hs-CRP were identified as independent predictors of AF.

Conclusions:

  • Elevated serum HMGB1 in AF patients may be linked to increased oxidative stress.
  • Targeting oxidative stress could be a potential therapeutic avenue for managing AF.
Abstract

Keywords:
High mobility group box 1 proteinatrial fibrillationinflammationoxidative stress

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