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Updated: May 5, 2026
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Update on randomized trials on recurrent disease.
1MD Anderson Cancer Center, Madrid, Spain.
Summary
Ovarian cancer recurrence is common. This review updates clinical trials on treatments like chemotherapy and antiangiogenic agents, offering survival benefits beyond palliation for recurrent disease.
Area of Science:
- Oncology
- Gynecologic Oncology
- Clinical Trials
Background:
- Advanced ovarian cancer frequently recurs within 3 years post-surgery and paclitaxel-carboplatin chemotherapy.
- Treatment decisions for recurrent ovarian cancer require careful consideration of disease, patient, and therapeutic factors.
- Effective strategies are crucial for both palliation and improving survival outcomes.
Purpose of the Study:
- To provide an updated review of clinical trials for recurrent ovarian cancer.
- To highlight advancements in treatment strategies beyond initial therapy.
- To discuss interventions impacting progression-free and overall survival.
Main Methods:
- Review of recent clinical trials in recurrent ovarian cancer.
- Analysis of data on single cytotoxic agents, combination therapies, and antiangiogenic agents.
- Inclusion of surgical management considerations (referenced in a companion article).
Main Results:
- Various treatment strategies, including cytotoxic agents and antiangiogenic therapies, demonstrate impact on progression-free survival.
- Some treatment approaches offer a survival benefit in patients with recurrent ovarian cancer.
- Recent advancements focus on novel combinations and targeted therapies.
Conclusions:
- Several treatment options exist for recurrent ovarian cancer, offering palliation and survival advantages.
- Antiangiogenic agents represent a significant recent advancement in managing recurrent disease.
- Continued research and clinical trials are essential for optimizing treatment of recurrent ovarian cancer.
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