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Updated: May 5, 2026

FISH for Pre-implantation Genetic Diagnosis
Published on: February 23, 2011
Double translocation: an interesting family history
1Department of Obstetrics and Gynecology, Çanakkale Onsekiz Mart University, Çanakkale, Turkey.
Abstract:
Double balanced translocations are particularly rare and the risk of a fetus with an unbalanced chromosomal anomaly is greater than for single translocation carriers. In this present case, we describe an interesting family history which included three generations. A couple, married for 4 years, was referred to the genetic clinic due to infertility and family chromosome anomalies. A GTG-band chromosome analysis indicated that the male partner's karyotype was 45,XY, t(3;18)(q11;ptel)t(13;14)(q10;q10). The same double balanced translocation was found in two others family members.
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