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Hyperhomocysteinemia in a young woman presenting with acute myocardial infarction: Case report

Seher Gokay1, Davran Ciçek, Haldun Müderrisoğlu

  • 1Faculty of Medicine, Baskent University Alanya, Antalya Turkey.

Interventional Medicine & Applied Science
|November 23, 2013
PubMed

Insights

Elevated homocysteine levels are linked to coronary artery disease. This case highlights the importance of measuring homocysteine in young women with acute coronary syndromes, even with traditional risk factors.

Area of Science:

  • Biochemistry
  • Cardiology
  • Clinical Medicine

Background:

  • Homocysteine (Hcy) is a sulfur-containing amino acid derived from methionine metabolism.
  • Elevated Hcy levels are a recognized risk factor for coronary artery disease (CAD).
  • Premature atherosclerosis in women presents unique diagnostic challenges.

Purpose of the Study:

  • To report a case of acute myocardial infarction (AMI) in a young woman.
  • To investigate the role of hyperhomocysteinemia as a potential contributor to AMI.
  • To emphasize the clinical utility of plasma Hcy measurement in women with premature CAD.

Main Methods:

  • Case report presentation.
  • Clinical evaluation of a 25-year-old female patient presenting with AMI.
  • Assessment of traditional CAD risk factors including smoking, LDL levels, and family history.
  • Plasma homocysteine level measurement.

Main Results:

  • The patient, a 25-year-old woman, experienced acute myocardial infarction.
  • Hyperhomocysteinemia was identified as a significant finding in this patient.
  • She also presented with other CAD risk factors: smoking, elevated LDL, and family history of sudden cardiac death.

Conclusions:

  • Hyperhomocysteinemia can be associated with acute coronary syndromes in young women.
  • Plasma homocysteine measurement should be considered in the diagnostic workup of women with premature atherosclerosis and acute coronary syndromes.
  • Early identification of elevated Hcy may aid in risk stratification and management of CAD in specific patient populations.

Keywords:
hyperhomocysteinemia, young, woman, myocardial infarction, risk factors

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