Related Experiment Video
Updated: May 5, 2026
07:43
In Vivo Quantification of Hip Arthrokinematics during Dynamic Weight-bearing Activities using Dual Fluoroscopy
Published on: July 2, 2021
2.9K
Joint shape morphogenesis precedes cavitation of the developing hip joint
1EMBL-CRG Systems Biology Program, Centre for Genomic Regulation, UPF, Barcelona, Spain; Department of Bioengineering, Imperial College, London, UK.
Journal of Anatomy
|November 26, 2013
Summary
Early hip joint development in embryonic chicks reveals major anatomical features form before cavitation. This challenges previous assumptions about joint shape formation and timing.
Area of Science:
- Developmental Biology
- Skeletal Biology
- Biomechanics
Background:
- Joint cavitation and mechanobiology are well-studied, but joint morphogenesis remains poorly understood.
- Understanding joint shape development is crucial for conditions like developmental dysplasia of the hip.
Purpose of the Study:
- To characterize early hip joint shape development in embryonic chicks.
- To investigate the temporal relationship between joint cavitation and morphogenesis.
Main Methods:
- Utilized direct capture 3D imaging for high-resolution analysis of embryonic chick hip joints.
- Examined developmental stages from Hamburger Hamilton (HH)32 to HH34.
Main Results:
- Major adult hip anatomical features are present at HH32, predating joint cavitation at HH34.
- Significant pelvic orientation changes occur before joint cavity formation.
- Ischium and pubis appearance identified at earlier developmental stages than previously reported.
Conclusions:
- Joint morphogenesis, specifically hip joint shape development, precedes cavitation.
- Direct capture 3D imaging provides novel insights into embryonic skeletal development.
- Findings challenge existing models of joint formation and have implications for understanding congenital hip malformations.
Related Concept Videos
01:07Development of the Limb Synovial Joints
5.0K
Joints form during embryonic development in conjunction with the formation and growth of the associated bones. The embryonic tissue that gives rise to all bones, cartilage, and connective tissues of the body is called mesenchyme.
The mesenchymal stem cells differentiate into chondrocytes that form the hyaline cartilage, and later the cartilaginous model of the bone. This model further transforms into a bone. This process is known as endochondral ossification.
During development, the limbs...
The mesenchymal stem cells differentiate into chondrocytes that form the hyaline cartilage, and later the cartilaginous model of the bone. This model further transforms into a bone. This process is known as endochondral ossification.
During development, the limbs...
5.0K
01:29Bone Formation by Intramembranous Ossification
16.2K
Intramembranous ossification is one of the two processes involved in the development of bones within an embryo. The flat bones of the face, most of the cranial bones, and the clavicles are formed via this process. During intramembranous ossification, the bones develop directly from sheets of undifferentiated mesenchymal connective tissue.
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into ...
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into ...
16.2K
01:24Bone Formation by Endochondral Ossification
14.7K
Bone formation, or ossification, begins around the sixth to seventh week of embryonic development. Most bones develop from a cartilaginous template through the process of endochondral ossification. Cartilage formation begins when clusters of mesenchymal cells differentiate into chondrocytes. These chondrocytes proliferate rapidly and secrete an extracellular matrix that becomes encased in a membrane called the perichondrium. The resulting cartilage model provides a template that resembles the...
14.7K
01:09Changes in the Appendicular Skeleton with Age
3.2K
The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
3.2K
01:27Growth of Cartilage and Bone Tissue
3.9K
Chondrocytes form a temporary cartilaginous model by dividing and secreting a thick gel-like extracellular matrix. Once the chondrocytes undergo programmed cell death, osteoblasts enter the site of the cartilaginous model. The process of replacing the temporary cartilaginous model with bone in an ordered manner is called endochondral ossification. In endochondral ossification, not all of the cartilage is replaced by bone tissue. Some cartilage that performs a protective and supportive function...
3.9K
01:17Structural Joints: Cartilaginous Joints
4.4K
As the name indicates, at a cartilaginous joint, the adjacent bones are united by cartilage, a tough but flexible type of connective tissue. Unlike synovial joints, these types of joints lack a joint cavity and involve bones joined together by either hyaline cartilage or fibrocartilage.
There are two types of cartilaginous joints:
Synchondrosis
A synchondrosis ("joined by cartilage") is a cartilaginous joint where bones are connected by hyaline cartilage. Synchondrosis may be temporary...
There are two types of cartilaginous joints:
Synchondrosis
A synchondrosis ("joined by cartilage") is a cartilaginous joint where bones are connected by hyaline cartilage. Synchondrosis may be temporary...
4.4K