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Updated: May 5, 2026
Heterogeneity Mapping of Protein Expression in Tumors using Quantitative Immunofluorescence
Published on: October 25, 2011
Prognostic significance of FRA expression in epithelial cancers using AQUA(®) technology
Daniel J O'Shannessy1, Mark Gustavson, Lakshmi Krupa Chandrasekaran
1Department of Diagnostics Development, Morphotek, Inc., 210 Welsh Pool Road, Exton, PA 19341, USA.
Aim:
Although agents that target FRA have advanced through clinical trials, comprehensive analyses of FRA expression in epithelial cancers compared with clinical variables and prognosis are limited.
Materials & Methods:
FRA expression was examined in non-small-cell lung cancer (NSCLC), ovarian cancer and endometrial cancer cohorts using AQUA(®) technology.
Results:
For the NSCLC cohort, FRA expression was significantly higher in adenocarcinoma samples (p < 0.001) than other histologies, and in females (p = 0.003) versus males. High FRA expression was significantly associated with better survival in NSCLC cases (p = 0.01) while significantly and independently associated with worse prognosis in endometrial (p < 0.001) and ovarian cancers (p < 0.001).
Conclusion:
These studies confirm the prognostic value of FRA in multiple indications. The opposing prognostic effects observed may suggest differential biology.
