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Related Concept Videos

Cholecystitis01:20

Cholecystitis

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Cholecystitis is inflammation of the gallbladder, most commonly caused by obstruction of the cystic duct. This blockage prevents bile from draining, leading to gallbladder distension, inflammation, and potentially serious complications. This condition may present acutely or chronically and can happen with or without gallstones.EtiologyAbout 95% of cholecystitis cases are calculous, caused by gallstones blocking the cystic duct, leading to bile accumulation and inflammation of the gallbladder...
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Diseases of the Liver and Gallbladder01:26

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Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
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Chronic Pancreatitis II: Pathophysiology01:21

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Chronic pancreatitis is a progressive and irreversible inflammation of the pancreas, most often caused by long-term alcohol abuse, but it can also be related to ductal obstruction, smoking, or genetic factors.Chronic pancreatitis occurs when the pancreas is repeatedly exposed to harmful agents like alcohol, smoking, ductal obstruction, or genetic predisposition. These factors lead to the release of toxic metabolites and inflammatory cytokines, sustaining chronic inflammation in the pancreatic...
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Cirrhosis I: Introduction01:23

Cirrhosis I: Introduction

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Cirrhosis is a chronic, irreversible liver disease characterized by the widespread replacement of healthy liver tissue with fibrotic scar tissue and the formation of regenerative nodules.Etiology of cirrhosisCirrhosis results from sustained liver injury that triggers progressive fibrosis and structural remodeling. The underlying causes are diverse, encompassing common and less frequent clinical conditions. Regardless of the origin, all causes lead to chronic inflammation, hepatocyte loss, and...
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Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

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The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
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Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
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Chronic Pancreatitis I: Introduction01:25

Chronic Pancreatitis I: Introduction

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Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80%...
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Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis
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Cholestatic liver disease.

Andrea A Gossard1, Jayant A Talwalkar

  • 1Cholestatic Liver Disease Study Group, Division of Gastroenterology and Hepatology, Mayo Clinic, 200 First Street SW, Rochester, MN, USA.

The Medical Clinics of North America
|November 26, 2013
PubMed
Summary
This summary is machine-generated.

Caring for patients with cholestasis involves diagnosing the cause, treating reversible factors, and managing chronic conditions. Primary biliary cholangitis (PBC) has effective treatments, unlike primary sclerosing cholangitis (PSC).

Keywords:
Bile duct obstructionBiliary tract diseaseCholestasisCholestatic liver diseasePrimary biliary cirrhosisPrimary sclerosing cholangitis

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Area of Science:

  • Hepatology
  • Gastroenterology
  • Internal Medicine

Background:

  • Cholestasis, a liver condition, requires careful management based on its cause.
  • Primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC) are leading causes of cholestatic liver disease.
  • Effective treatments exist for PBC, but not for PSC.

Purpose of the Study:

  • To outline the essential components of managing patients with cholestasis.
  • To differentiate the therapeutic approaches for PBC and PSC.
  • To emphasize the importance of recognizing and managing cholestasis complications.

Main Methods:

  • Review of current medical literature on cholestasis.
  • Analysis of diagnostic and therapeutic strategies for PBC and PSC.
  • Discussion of complication management in chronic cholestatic liver disease.

Main Results:

  • Identification of etiology and treatment of reversible causes are key to cholestasis care.
  • PBC management has effective therapies, while PSC lacks specific treatments.
  • Proactive management of cholestasis-associated complications is crucial.

Conclusions:

  • Comprehensive patient care for cholestasis necessitates etiological diagnosis and management.
  • The distinct therapeutic landscapes for PBC and PSC require tailored clinical strategies.
  • Vigilance for and management of cholestasis complications are integral to patient outcomes.