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Transcription

Transcription

Overview
Transcription is the process of synthesizing RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene sequence. Additionally, many other proteins and regulatory sequences are involved in the proper synthesis of messenger RNA (mRNA). Regulation of transcription is responsible for the differentiation of all the different types of cells and often for the proper cellular response to environmental signals.
Transcription Can Produce Different Kinds...

Transcription

Transcription

Transcription is the synthesis of RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene sequence. Additionally, many other proteins and regulatory sequences are involved in correctly synthesizing messenger RNA (mRNA). Transcriptional regulation is responsible for the differentiation of different types of cells and often for the proper cellular response to environmental signals.
Transcription Can Produce Different Kinds of RNA Molecules
In eukaryotes,...

Transcription

Transcription

Transcription

Transcription

Transcription Attenuation in Prokaryotes

Transcription Attenuation in Prokaryotes

Transcriptional attenuation occurs when RNA transcription is prematurely terminated due to the formation of a terminator mRNA hairpin structure. Bacteria use these hairpins to regulate the transcription process and control the synthesis of several amino acids including histidine, lysine, threonine, and phenylalanine. Transcription attenuation takes place in the non-coding regions of mRNA.
There are several different mechanisms used to attenuate transcription. In ribosome mediated...

Cooperative Binding of Transcription Regulators

Cooperative Binding of Transcription Regulators

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Related Experiment Video

Updated: May 5, 2026

Analysis of Termination of Transcription Using BrUTP-strand-specific Transcription Run-on TRO Approach

Analysis of Termination of Transcription Using BrUTP-strand-specific Transcription Run-on TRO Approach

Published on: March 12, 2017

Dealing with pervasive transcription.

Torben Heick Jensen¹, Alain Jacquier, Domenico Libri

¹Centre for mRNP Biogenesis and Metabolism, Department of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus C., Denmark.

|November 26, 2013

Summary

Eukaryotic genomes are pervasively transcribed, but the function of many resulting RNAs remains unknown. This review explores how cells regulate these pervasive transcripts, influencing their potential molecular function.

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Last Updated: May 5, 2026

Analysis of Termination of Transcription Using BrUTP-strand-specific Transcription Run-on TRO Approach

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Area of Science:

Molecular Biology
Genomics
RNA Biology

Background:

Eukaryotic genomes exhibit pervasive transcription, producing numerous RNA molecules.
The functional significance of many newly identified RNAs is not well understood.
Distinguishing functional RNAs from spurious transcription byproducts is a key challenge.

Purpose of the Study:

To review the mechanisms controlling the production and turnover of pervasive transcripts in eukaryotic cells.
To discuss the factors influencing the potential molecular function of these transcripts.
To use model organisms like S. cerevisiae and mammalian cells to illustrate these processes.

Main Methods:

Literature review focusing on gene expression regulation.
Comparative analysis of transcript regulation in S. cerevisiae and mammalian cells.
Discussion of RNA synthesis, termination, and decay pathways.

Main Results:

Cells employ mechanisms to limit the accumulation of opportunistic transcripts.
Regulation involves controlling RNA synthesis and promoting early transcription termination and decay.
The turnover rate of pervasive transcripts is a critical determinant of their potential function.

Conclusions:

Understanding the regulation of pervasive transcripts is crucial for deciphering their roles.
The balance between transcript production and degradation influences the likelihood of molecular function.
Model systems provide insights into conserved mechanisms of RNA regulation.