Related Experiment Video
Updated: May 5, 2026

Early Detection of Cyanobacterial Blooms and Associated Cyanotoxins using Fast Detection Strategy
Published on: February 25, 2021
Sex hormonal disruption by cyanobacterial bioactive compounds
1Biology Department, Faculty of Science, Jazan University, Jazan, Saudi Arabia; Botany Department, Faculty of Science, Fayoum University, Fayoum, Egypt.
Aims:
This study investigated the effect of some cyanobacterial exudates on the level of sex hormones in a mammalian model and to identify the molecules that could act as endocrine disruptor.
Methods And Results:
In this study, the cytotoxicity of purified exudates of some axenic cyanobacterial cultures (Nostoc ellipsosporum, Nostoc muscorum, Anabaena oryzae & Anabaena. sp.) was evaluated against normal melanocyte cell line (HFB4). The intraperitoneal injection of the cyanobacterial exudates demonstrated a marked disturbance in the serum level of testosterone, progesterone, follicular stimulating hormone (FSH) and luteinizing hormone (LH) of male mice. GC-MS and LC-MS/MS analysis showed the presence of some sterol-like compounds in the cyanobacterial filtrates.
Conclusions:
This work demonstrated that the nontoxic cyanobacterial species have the ability to produce some bioactive compounds into their surroundings that can disrupt the mammalian reproductive hormones.
Significance And Impact Of Study:
The cyanobacterial extracellular bioactive molecules can affect on the production of the sex hormones via positive and negative feedback and may be a risk to human beings.
Related Concept Videos
Bacterial Phylum Cyanobacteria
Bioactivation and Tissue Toxicity
Bioremediation
Red Algae
Types of Toxins
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
Factors Affecting Drug Biotransformation: Biological
Species differences: Variations in enzyme systems across species can cause disparities in drug metabolism. For instance, humans may metabolize certain drugs faster than rodents, altering therapeutic effects.
Strain differences: Genetic variations within a species can result in differing enzyme activity, impacting drug response and toxicity. For example, some mouse strains may...

