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Gout and the heart

Vidula Bhole1, Eswar Krishnan

  • 1515 Olmsted Road, Palo Alto, CA 94305, USA.

Rheumatic Diseases Clinics of North America
|November 26, 2013
PubMed

Insights

Gout is strongly linked to cardiovascular diseases, with consistent evidence from numerous studies. Further research is needed to understand gout's independent impact beyond high uric acid levels.

Area of Science:

  • Rheumatology
  • Cardiology
  • Epidemiology

Background:

  • The link between gout and cardiovascular diseases (CVD) is historically recognized.
  • Recent epidemiological studies consistently confirm a strong association between gout and CVD.
  • The independent contribution of gout to cardiovascular risk, beyond hyperuricemia, requires further investigation.

Purpose of the Study:

  • To review the epidemiological evidence on the association between gout and cardiovascular diseases.
  • To highlight the need for studies clarifying gout's specific impact on cardiovascular risk.

Main Methods:

  • Literature review of published epidemiological studies.
  • Analysis of the consistency and strength of the association between gout and cardiovascular outcomes.

Main Results:

  • The published literature demonstrates a consistent and strong association between gout and cardiovascular diseases.
  • Evidence suggests a significant link, but the extent of gout's impact independent of other risk factors is not fully elucidated.

Conclusions:

  • A robust association exists between gout and cardiovascular diseases.
  • Further research is essential to elucidate the pathophysiological mechanisms and the independent role of gout in cardiovascular disease development.

Keywords:
CoronaryGoutMortalityRisk cardiovascularUric acid

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