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Antithrombotic effects of PAR1 and PAR4 antagonists evaluated under flow and static conditions

Kazuya Hosokawa1, Tomoko Ohnishi2, Naoki Miura3

  • 1Research Institute, Fujimori Kogyo Co., Ltd., Yokohama, Kanagawa, Japan; Department of System Biology in Thromboregulation, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.

Thrombosis Research
|November 26, 2013
PubMed
Abstract

Keywords:
ACSADPAPASPAUAUCCFTCTCTIETPFlow chamberGPLTMCFOTPARPHPPPPRPPlateletProtease-activated receptorT-TASTFTGTTPTXA(2)ThrombinThrombus formationactivating peptideacute coronary syndromeadenosine 5’-diphosphateaggregation unitsarea under the aggregation curveaspirinclot formation timeclotting timecorn trypsin inhibitorendogenous thrombin generation potentialglycoproteinlag timemaximum clot firmnessocclusion timepeak heightplatelet-poor plasmaplatelet-rich plasmaprotease-activated receptorr-TFrecombinant tissue factorthrombin generationthromboxane A(2)time to peaktissue factortotal thrombus-formation analysis system

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