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Updated: May 5, 2026

Tilt Testing with Combined Lower Body Negative Pressure: a "Gold Standard" for Measuring Orthostatic Tolerance
Published on: March 21, 2013
Orthostatic hypotension secondary to CRMP-5 paraneoplastic autonomic neuropathy
Andrew J Neal1, Mary Y Qian2, Alexandra S Clinch2
1Department of Neurology, Royal Melbourne Hospital, Grattan Street, Parkville, Melbourne, VIC 3052, Australia.
Abstract:
The collapsin response mediator protein 5 (CRMP-5) autoantibody is one of only several paraneoplastic antibodies associated with autonomic neuropathy. Such paraneoplastic neuropathies manifest with a constellation of autonomic abnormalities. We present a unique case of orthostatic hypotension as the sole feature of a CRMP-5 paraneoplastic autonomic neuropathy in a patient with small cell lung cancer. Given the poor prognosis of paraneoplastic autonomic dysfunction, it is important to accurately diagnose the cause of orthostatic hypotension occurring on a background of malignancy.
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