Prognostic factors in patients with head and neck squamous cell carcinoma with cN3 neck disease: a retrospective
Jae Hoon Jung1, Jong-Lyel Roh1, Jeong Hyun Lee2
1Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Objective:
This study examined prognostic factors in patients with head and neck squamous cell carcinoma with advanced neck disease.
Study Design:
The records of 191 patients with previously untreated head and neck squamous cell carcinoma and metastatic cervical lymph node (LN) >6 cm (cN, n = 70) and 3.01 to 6 cm (control, n = 121) in the greatest dimension were reviewed. Univariate and multivariate analyses were used to identify factors associated with disease-free survival (DFS) and locoregional control (LRC).
Results:
In the cN3 group, independent variables for DFS were age, active drinking, LN size, and extranodal extension (P < .05), and that for LRC was age (P = .025). In the control group, independent variables for DFS were tumor location and differentiation and LN bilaterality (P < .05), and that for LRC was LN bilaterality (P = .011).
Conclusions:
The survival of cN3 patients is affected by host and nodal characteristics including age, drinking, nodal size, and extranodal extension.
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