Related Experiment Video
Updated: May 5, 2026

Isolation of Primary Mouse Retinal Pigmented Epithelium Cells
Published on: November 4, 2022
Hyperhomocysteinemia in chronic alcoholism: A case with retinal manifestations
L Palmero-Fernández1, F Fernández-Treguerres1, E Santos-Bueso1
1Departamento de Neuro-oftalmología, Hospital Clínico San Carlos, Madrid, España.
Case Report:
An alcoholic patient with loss of vision in his right eye and a peripapillar haemorrhage, who then presented with a venous thrombosis. Blood analysis revealed hyperhomocysteinemia with coagulation parameters within the normal range. In the follow-up he developed a bilateral optic neuropathy.
Discussion:
An increase in homocysteine levels is common in alcoholics, and it has been considered a vascular risk factor. Folic acid and vitamins B6 and B12 deficiency may lead to hyperhomocysteinemia, as they participate in its metabolism.
Conclusions:
When presented with a retinal occlusive disease or ischemic optic neuropathy in young patients, coagulation disorders and elevated levels of homocysteine should be ruled out.
Related Concept Videos
Chronic Pancreatitis II: Pathophysiology
Cirrhosis II: Pathophysiology
Chronic Kidney Disease II: Clinical Manifestations
Diabetic Retinopathy
Cirrhosis I: Introduction
Chronic Pancreatitis I: Introduction
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...

